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The theory, methods, and practices needed to generate and screen very large, high-quality, small molecule, and DNA-encoded libraries

Describing the development and practice of DNA-encoded library synthesis technology, this book expertly details an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery, and fragment-based screening. A Handbook for DNA-Encoded Chemistry is comprised of chapters summarizing practical methods, theoretical analysis, and reported applications. Important aspects of this technology, including DNA-compatible chemistry, DNA-encoded library synthesis, design of “chemical genes,” analytical methods for small molecule-DNA libraries, selection methods, hit identification, and DNA-directed chemistry are explored.

This book offers practicing chemists a variety of benefits:

  • Guidance for understanding and applying DNA-encoded combinatorial chemistry to generate and screen novel chemical libraries
  • A bridge to the interdisciplinary areas of DNA-encoded combinatorial chemistry—synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
  • Instruction for medicinal and pharmaceutical chemists to efficiently broaden available “chemical space” for drug discovery
  • Expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

Despite many publications from laboratories specializing in DNA-encoded chemistry published since 1992, there has been no technical handbook offering this level of detail.

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