Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions, 2nd Edition

The quest for making molecules in a stereochemically-defined manner continues without any signs of a loss of interest. This is particularly true of the pharmaceutical and fine chemicals industries, and this has fueled the search for novel technologies and methods to achieve this, both in academia and within the industry. This second collection of case studies captures the trends and major achievements in the art of making chiral chemical compounds on an industrial scale. Included is the development of as many large-scale enantioselective processes as possible, showing the "real life" applications of this challenging field. As a result, first-hand and valuable information is collated within the one monograph where it can be easily accessible. The contributions illustrate the relevant environments and situations, such as time pressure, the fit of the catalytic step into the over-all synthesis, or competition with other synthetic approaches, as well as the typical problems encountered in the various phases, such as finding/developing the catalyst, optimization of the process or choice of equipment, etc.