Biophysical Analysis of Membrane Proteins: Investigating Structure and Function

Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is a cutting-edge resource for the major biophysical methods that are - or soon will be- the major techniques used in the field. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Each chapter is dedicated to a specific approach, describing the method involved, highlighting the experimental procedure and/or the basic principles, offering an up-to-date understanding of what is measured, what can be deduced from the measurements, as well as the limitations of each procedure.

Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopes, finishing off with an exploration of structure-function relationships in whole cells.