With contributions from leaders in the field, this comprehensive text considers the in vitro uses of stem cells for the detection of compounds that pose risk of birth defects. In addition, this text describes approaches to elucidate cellular and molecular mechanisms involved in the birth defect causation. Also of interest, this book contains accounts of impacts upon endogenous stem cells in vivo that lead to dysfunction relevant for human health.
Stem Cells in Birth Defects Research and Developmental Toxicology includes contributions from leading experts in the field to offer a unique perspective on the topic that considers both in vitro uses of stem cells as platforms for teratology, and also "stem cellopathies." Stem cellopathies are human developmental and degenerative disorders that are caused by harmful impacts to resident adult stem cells in vivo.
The text’s introduction provides an overview of basic stem cell function and applications and covers the uses of stem cells for in vitro assays to detect suspected teratogens. The expert authors include information on human "stem cellopathies," and review the most current technical innovations in stem cell bioassays. This important resource:
- Contains important platforms and recent accounts of the state of stem cell research in the fields of toxicology and teratology
- Offers information on both in vitro uses of stem cells as platforms for teratology and stem cellopathies
- Contains a helpful guide for the pharmaceutical industry and safety and environmental authorities to validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives
- Features chapters from leaders at the interface of stem cell research and applied science
Written for toxicologists, stem cell researchers, epigeneticists, teratologists, pharmaceutical scientists, developmental biologists, and neonatologists, Stem Cells in Birth Defects Research and Developmental Toxicology offers a guide aimed at improving human fetal safety and the understanding of human developmental and degenerative disorders.
