Multivalency: Concepts, Research & Applications

Multivalency: Concepts, Research & Applications connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications.

The book is divided into two parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics, and the principle of effective molarity are described, and characterization methods, experimental methodologies and data treatment methods are also discussed.

Part two provides an overview of current systems in which multivalency plays an important role, with a focus on the design rules, underlying chemistry, and the fundamental principles of multivalency. The systems discussed range from chemical/materials-based systems such as dendrimers and sensors, to biological systems including cell recognition and protein binding.  Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book.

This advanced textbook will provide students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field.