The Human Genome Project was completed in 2003, as a result of sequencing the whole genome of an individual by Sanger sequencing technique. After the completion of Human Genome Project over a decade ago, medical genomics techniques have become commonly used tools in order to develop new diagnostic strategies, treatment applications and prevention methods in both Mendelian disorders and common, genetically complex diseases. Rapid achievements in the whole genome sequencing technologies forced researchers to focus on next generation sequencing to utilize entire genomic data in association with human genetic disorders.
The next generation genomic technologies allow scientists to better understand the genetic causes of the diseases. These approaches provide scientists with increased amount of genomic data through sequencing of multiple areas in the genome. With the combination of the new informatics methods, the data permits researchers get accurate information of the genome and diseases. After these scientific and technological developments, information about whole genome sequencing has become essential to nearly all researchers in any disciplines dealing with clinical diagnosis. There is increasing awareness of genetic aspects of diseases among both clinicians and their patients, but there is a need for an informative book for clinicians about utilization of genomic technologies that can be used in their daily practice.
This book provides general information about principles of genomics, next generation genomics technologies and their use in the clinics are reviewed in order to contribute to the knowledge of the newly emerging medical genomics field with case examples in an easy to follow aspect.
