Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification

With its focus on quantitative methods and weight of the evidence, Cancer Risk Assessment enables readers to accurately assess human cancer risk from exposure to chemical agents, including solvents, metals, mixtures, and nanoparticles. Moreover, the book helps readers understand the link between cancer risk and the basic toxicology and biology of cancer.

Each chapter of this contributed work has been written by one or more leading international experts. Their contributions integrate a comprehensive review of the scientific literature with their own personal hands-on experience as well as their knowledge of current regulations and testing guidelines. With the authors' guidance, readers can better analyze toxicological data in order to reduce the uncertainties in chemical-related cancer evaluations and risk assessments.

The book begins with an overview of cancer risk assessment, science policy, and the regulatory framework for industrial chemicals and biocides. Next, all the core concepts, skills, and methods needed to perform cancer risk assessments are covered in detail, including:

• Key fundamentals in cancer biology, chemical carcinogenesis, hormesis, and experimental evidence of thresholds for genotoxic carcinogens
• Testing guidelines and regulations for in vitro and in vivo genotoxicity testing
• Evaluation of toxicological data and its relevance to hazard evaluation and cancer risk estimation
• Methods for quantifying cancer risk, including quantitative structure-activity relationships, physiologically-based pharmacokinetic modeling, "-omics," and computational toxicology

Readers of Cancer Risk Assessment not only learn to perform state-of-the-science cancer risk assessments, but also gain valuable skills and knowledge in the more general fields of toxicology and risk assessment.